Skip to main content
. 2020 Dec 30;11(1):37. doi: 10.3390/biom11010037

Figure 5.

Figure 5

Network and biological pathway analysis of pathway analysis and protein–protein interactions. (A) The Metascape analysis shows the top 20 clusters of enriched sets. Left panel, heatmap of the 20 enriched terms. (B) Representative Molecular Complex Detection network node showing DEG regulated by UBE2C. (C) UBE2C and PIK3CA-TP53 pathways, identified by curated analysis, and the proliferation pathway, cell cycle progression, cell survival pathway identified by cBioPortal for Cancer Genomics. (D) Correlation analysis between UBE2C and mTOR, AKT, PI3K, PTEN, MAPK expression in tumors prepared with mRNA available in TCGA. (E–H) Loss-of-function and gain-of-function protein expression and cancer cell survival rate. * p < 0.05, ** p < 0.01, and *** p < 0.001.