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. 2020 Dec 24;10(1):19. doi: 10.3390/cells10010019

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Summary of the in vitro and in vivo functions of Siglec-8 on eosinophils and mast cells. (Left) Eosinophil-specific activity of Siglec-8 mAbs or glycan-ligands. (Right) Mast cell-specific activity of Siglec-8 mAbs. (Bottom) Anti-inflammatory activity of targeting both eosinophils and mast cells with Siglec-8 mAbs. ADCC, antibody-dependent cellular cytotoxicity; AKC, atopic keratoconjunctivitis; CSU, chronic spontaneous urticaria; EG/EoD, eosinophilic gastritis/eosinophilic duodenitis; ISM, indolent systemic mastocytosis.