Table 2.
Variable comparisons for MTHFR C677T gene polymorphism (n = 44) and MTHFR A1298C gene polymorphism (n = 16) using Mann- Whitney U Test, Chi Square Test and Fisher’s Test.
| Variable | With MTHFR C677T Polymorphism (n = 44) | With MTHFR A1298C Polymorphism (n = 16) | p | ||
|---|---|---|---|---|---|
| Mean +/− Std Deviation (Median) | Mean Rank | Mean +/− Std Deviation (Median) | Mean Rank | ||
| Age, years | 35.3 ± 8.47 | 35.89 | 34.36 ± 8.5 | 33.76 | 0.548 |
| Male, n (%) | 16 (36.37%) | 13.76 | 6 (37.50%) | 8.23 | p < 0.001 * |
| Female, n (%) | 28 (63.63%) | 23.95 | 10 (62.50%) | 14.04 | p < 0.001 * |
| HTN 1, n (%) | 10 (22.72%) | 8.66 | 4 (25.00%) | 5.33 | 0.002 * |
| SPB 2, mmHg | 127.61 ± 22.51 | 131.03 | 129.06 ± 22.62 | 125.63 | 0.264 |
| DBP 3, mmHg | 79.88 ± 13.55 | 82.80 | 83.75 ± 13.44 | 80.82 | 0.326 |
| SSS 4/SSS + LS 5 | 25 (56.81%) | 20.88 | 7 (43.75%) | 11.11 | p < 0.001 * |
| LS/LS + SP 6/LS + SS 7, n (%) | 15 (34.09%) | 12.73 | 5 (31.25%) | 7.26 | p < 0.010 * |
| Cav. S 8, n (%) | 4 (9.09%) | 4.09 | 4 (25.00%) | 3.90 | 0.722^ |
| Factor V 9, n (%) | 16 (36.36%) | 12.71 | 2 (12.50%) | 5.28 | p < 0.001 * |
| Factor II 10, n (%) | 0 | 0.78 | 3 (18.75%) | 2.21 | 0.076 ^ |
| PAI-1 11, n (%) | 38 (86.36%) | 31.83 | 11 (68.75%) | 17.16 | p < 0.001 * |
| tHcy 12, μmol/L | 45.05 ± 34.13 | 38.82 | 17.19 ± 34.31 | 23.41 | p < 0.001 * |
| TC 13, mg/dL | 198.45 ± 38.36 | 206.16 | 209.81 ± 38.17 | 202.09 | 0.108 |
| LDLc 14, mg/dL | 115.2 ± 26.74 | 118.06 | 115.62 ± 27.51 | 112.75 | 0.292 |
| HDLc 15, mg/dL | 50.36 ± 12.97 | 52.53 | 54.06 ± 12.74 | 51.88 | 0.385 |
| TGL 16, mg/dL | 135.81 ± 75.56 | 141.75 | 146.12 ± 75.95 | 140.17 | 0.149 |
| Blood glucose 17 | 100.31 ± 39.84 | 103.17 | 102.12 ± 39.63 | 99.25 | 0.316 |
| HbA1c 18, % | 5.5 ± 1.53 | 5.64 | 5.55 ± 1.53 | 5.40 | 0.817 |
| hsCRP 19, mg/L | 7.25 ± 2.93 | 7.28 | 6.74 ± 2.85 | 6.70 | 0.745 |
| IMT 20, mm | 0.92 ± 0.18 | 0.94 | 0.94 ± 0.18 | 0.91 | 0.923 |
* Mann-Whitney U Test and Chi Square Test significant difference; ^ Fisher’s test significant difference; n = absolute number of patients; % = relative number of patients; 1 HTN, hypertension; 2 SBP, systolic blood pressure; 3 DBP, diastolic blood pressure; 4 SSS, superior sagittal sinus; 5 LS, lateral sinus; 6 PS, petrosal sinus; 7 SS, sigmoid sinus; 8 Cav. S, cavernous sinus; 9 Factor V G1691A- Leiden gene mutation (polymorphic variant); 10 Factor II, prothrombin G20210A gene mutation (polymorphic variant); 11 PAI-1, plasminogen activator- inhibitor gene mutation (polymorphic variant); 12 tHcy, homocysteine; 13 TC, total cholesterol; 14 LDLc, low- density lipoprotein cholesterol; 15 HDLc, high- density lipoprotein cholesterol; 16 TGL, triglycerides; 17 Blood glucose, mg/dL; 18 HbA1c, glycohemoglobin; 19 hsCRP, high sensitive C- reactive protein; 20 IMT, intima- media thickness.