Figure 5.

In vivo characteristics of intravenously injected 3OMG, Glc and 2DG. (a) Three-compartment schematic illustration of transport and metabolism of Glc, 2DG, and 3OMG in normal brain. Intravascular, extravascular–extracellular, and intracellular pools are considered. Molecules with red label indicate non-metabolizable. (b) Glucose or glucose analogs were intravenously injected into normal rats. Rat brain R1ρ changes by 1 g/kg administration of d-glucose (Glc, n = 4), 2DG (n = 4) and 3OMG (n = 5) were plotted, where the injection time is indicated by the gray arrow. (Reprinted with permission from Ref [121]).