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Adaptation to hypoxic tumor microenvironments. Hypoxia decreases αKG-dependent dioxygenase activity such as prolyl hydroxylases (PHDs) and histone lysine demethylases (KDMs), which affect cancer cell property and histone H3 methylation status. HIF; hypoxia-inducible factor, EMT; epithelial-to-mesenchymal transition, MMPs; Matrix metalloproteinases.
