Table 2.

List of newly reported molecules that play roles in CPN axon guidance.

Molecule	Molecular Function	Cortical Expression	Interacting Pathway	Roles in Callosal Axon Development	Reference
APP	Receptor-like membrane protein	Embryonic and neonatal CC and neuronal cell body in layer V	Slit/Robo	Serves as a Slit receptor and mediates axon repulsion	[107]
HSC70	Molecular chaperone of the heat shock protein 70 (HSP70) family	Preferentially expressed in neurons	Netrin/DCC	Required for the stability of DCC/TRIO complex at the growth cone to mediate axon outgrowth and guidance	[108]
PLCγ1	Signal transducer of receptor tyrosine kinases	Broadly expressed in the brain from embryonic to adult stages; strongly expressed in the cortex	Netrin/DCC	Triggers actin rearrangement for axonal growth	[109]
MARCKS	Cellular substrate for protein kinase C; F-actin crosslinking protein	Ubiquitous	Netrin/DCC	Mediates DCC activation via membrane recruitment of tyrosine kinases PTK2 and SRC	[110,111]
GPM6A and GPM6B	Glycoprotein localized in cholesterol-rich lipid rafts of the plasma membrane	Expressed in actively elongating axons in embryonic and neonatal brain		Extension and guidance of callosal axons	[112,113]