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(A): Cumulative release of colistin from PLGA microspheres showing initial burst, lag phase and a second slower release. SEM images of external and internal PLGA microsphere morphology. (B): In vitro colistin release from PMMA cements modified with CMC and antibiotic-loaded PLGA microspheres showed that higher porosity compositions had greater cumulative release of antibiotic, but it occurs in the second release phase. (Adapted and reprinted with permission from Shi et al. [90]).
