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View full-text article in PMC

. 2021 Jan 1;9(1):26. doi: 10.3390/biomedicines9010026

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

A new design for controlling antibiotic elution from PMMA cements by using coated ceramic particles as additives [102]. Porous ceramic particles are loaded with antibiotics by absorption (A). These particles are then coated in a biodegradable polymer coating consisted of PLGA which also contains antibiotics (B). The antibiotics in the biodegradable polymer coating release as the polymer swells and degrades, and create voids in the coating (C). The antibiotics in the ceramic particles release through these voids and the swollen/degrading polymer. These coated ceramic particles are designed to be mixed into PMMA to form an antibiotic-loaded cement whose antibiotic release can be controlled by multiple factors such as the antibiotic loading, the coating layer, the particle loading of the cement. The ceramic particles can be chosen to degrade, creating large pores in the cement which will facilitate bone ingrowth.