Table 4.

Variation in release from antibiotic-loaded cements. Maximum local antibiotic concentration in hip joint fluid eluted from antibiotic-loaded spacer. Adapted and reprinted with permission from Anagnostakos et al. [79].

Cement Used and Reference	Antibiotic Amount per 40 g Cement Powder	Antibiotic Powder Combination	Hour 1	Day 1	Day 2	Day 7	Week 2	Week 6
			(All Values Are in μg/mL)
Palacos [80]	2 g	Vancomycin		72		6.6
	0.5 g	Gentamicin		39		1.9
Palacos [81]	1 g	Clindamycin
	1 g	Gentamicin	30.61		53.9
Cemex [50]	1 g	Vancomycin		28.8
	0.76 g	Gentamicin		88
Simplex [82]	4 g	Vancomycin		1538		571.9		>MIC
	4 g	Azertonam		1003		313.6		>MIC
Simplex [67]	3 g	Vancomycin		485.5		76.1
	480 mg	Gentamicin (liquid)		58.3		14.6
Prepare in house [83]	2 g	Vancomycin		57
	-	Gentamicin
Palacos [84]	2 g	Vancomycin					<MIC
	0.5 g	Gentamicin					<MIC
Cemex [68]	150–170 mg	Vancomycin		13.8-40
	1 g	Gentamicin		15–90
Palacos [74]	2 g	Vancomycin						50
	1 g	Gentamicin						177
	1 g	Clindamycin						322