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Effect of metformin (MF) and/or chitosan stabilized nanoparticles (CH-SeNPs) oral dosing for 60 days on mRNA expression of (A) aromatase gene (CYP19A1), (B) peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and (C) Silent information regulator type-1 (SIRT1) in the testicular tissues of HFD/STZ diabetic male rats. Data expressed as mean ± SE, n = 15 for each group. Each bar carrying different letters (a–d) was significantly different at p < 0.05.
