Table 3.
Results of antibacterial, sortase A inhibitory, and cytotoxic assays of compounds 1–14.
| Antibacterial Activity MIC (μg/mL) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gram (+) Positive | Gram (−) Negative | IC50 (μM) | |||||||
| No. | S. aureus | Enterococcus faecalis | Enterococcus faecium | Klebsiella pneumonia | Salmonella enterica | E. coli | Srt A | A549 | K562 |
| 1 | >128 | >128 | >128 | >128 | >128 | >128 | >329.8 | 77.3 | 24.2 |
| 2 | 64 | >128 | >128 | 128 | 128 | >128 | 62.7 | 55.7 | 28.5 |
| 3 | 32 | 128 | >128 | >128 | 64 | >128 | 43.9 | 61.2 | 37.7 |
| 4 | 16 | 128 | 128 | >128 | 64 | >128 | >274.7 | 70.9 | 54.2 |
| 5 | >128 | >128 | >128 | >128 | >128 | >128 | 79.4 | >100 | 92.8 |
| 6 | 64 | >128 | >128 | >128 | 128 | >128 | 52.4 | >100 | >100 |
| 7 | 32 | 64 | 64 | 64 | 64 | >128 | >374.1 | 25.3 | 15.3 |
| 8 | 32 | >128 | >128 | >128 | >128 | >128 | 41.3 | 22.7 | 12.5 |
| 9 | 32 | >128 | >128 | >128 | >128 | >128 | 34.0 | 29.5 | 14.4 |
| 10 | 8 | 32 | 16 | 64 | 16 | >128 | 53.2 | 38.9 | 43.2 |
| 11 | 8 | 32 | 32 | 8 | 16 | >128 | 47.5 | 39.6 | >100 |
| 12 | 8 | 16 | >128 | 8 | 8 | >128 | >263.4 | 34.3 | 9.7 |
| 13 | 128 | >128 | >128 | >128 | >128 | >128 | 164.4 | 59.2 | >100 |
| 14 | 128 | >128 | >128 | >128 | >128 | >128 | 191.1 | 66.8 | >100 |
| ampicillin | 0.13 | 0.5 | 1 | ND a | 0.25 | 8 | |||
| tetracycline | ND a | ND a | ND a | 0.25 | ND a | ND a | |||
| triphasiol | 37.9 | ||||||||
| berberine chloride | 87.4 | ||||||||
| doxorubicin | 0.64 | 0.92 | |||||||
a Not detected.