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. 2020 Dec 29;8(1):3. doi: 10.3390/bioengineering8010003

Figure 4.

Figure 4

Ranking of ligand accessibilities to crucial binding sites and functional sequences in the native and proteolyzed type I collagen fibril. (A) Key functional domains of collagen were mapped onto a model of the fibril surface viewed from the fibril’s exterior. A molecular accessibility ranking of various ligands to their binding sites was determined for the static fibril, and following MMP-1 cleavage of M4 and “opening up” of the fibril. (B) View of the fibril’s GFOGER and Von Willebrand’s Factor (vWF)-binding sites following MMP-1 cleavage of M4. Reprinted with permission from [50].