Table 1.

In vitro activity of different antifungal drugs, PTS, and PTSO against Candida spp.

Species of Yeasts (Number of Isolates)	Range of MIC (in mg/L)	MIC50 (in mg/L)	MIC90 (in mg/L)	Range of MFC (in mg/L)	MFC50 (in mg/L)	MFC90 (in mg/L)	Number of Resistant Isolates
Candida albicans (n = 83)
Amphotericin B	0.125–0.25	0.25	0.25	1–16	4	8	0
Anidulafungin	≤0.008–0.25	0.015	0.06	0.015–>4	0.25	1	0
Micafungin	≤0.008–0.25	0.03	0.125	0.03–4	0.5	2	0
Caspofungin	≤0.008–0.25	0.06	0.06	0.06–4	0.5	2	0
Fluconazole	≤0.125–2	0.25	2	8–>64	>64	>64	0
Voriconazole	≤0.008–0.06	≤0.008	≤0.008	0.03–0.5	0.5	0.5	0
PTS	16–64	32	32	16–>128	32	128	-
PTSO	8–64	16	32	8–128	32	64	-
Candida glabrata (n = 73)
Amphotericin B	0.06–1	0.25	0.5	1–>16	4	8	0
Anidulafungin	≤0.008–0.125	0.015	0.03	0.06–>4	0.25	0.5	0
Micafungin	≤0.008–0.06	≤0.008	0.03	0.008–4	0.06	0.25	0
Caspofungin	≤0.008–0.125	0.03	0.03	0.06–4	1	2	0
Fluconazole	0.25–≥64	4	≥64	16–>64	>64	>64	73
Voriconazole	0.03–≥4	0.5	≥4	2–>4	>4	>4	73
PTS	8–64	32	32	16–>128	64	128	-
PTSO	16–32	16	32	8–>128	32	64	-
Candida krusei (n = 12)
Amphotericin B	0.25–1	0.5	1	4–16	8	16	0
Anidulafungin	≤0.008–0.06	0.015	0.03	0.125–0.5	0.25	0.5	0
Micafungin	0.06–0.25	0.125	0.125	0.5–4	0.5	1	0
Caspofungin	0.06–0.25	0.125	0.25	1–4	1	2	0
Fluconazole	8–≥64	16	≥64	>64	>64	>64	12
Voriconazole	0.03–0.5	0.125	0.5	2–>4	>4	>4	0
PTS	4–32	16	32	32–>128	32	128	-
PTSO	4–16	4	8	64–>128	128	128	-
Candida tropicalis (n = 35)
Amphotericin B	≤0.03–1	0.125	0.25	2–16	2	8	0
Anidulafungin	≤0.008–0.25	0.06	0.25	0.015–2	1	2	0
Micafungin	≤0.008–0.25	0.06	0.25	0.008–2	0.5	2	0
Caspofungin	≤0.008–0.25	0.06	0.25	0.06–4	1	4	0
Fluconazole	≤0.125–2	≤0.125	1	8–>64	>64	>64	0
Voriconazole	≤0.008–0.06	≤0.008	0.015	0.03–0.5	0.5	0.5	0
PTS	32–64	64	64	64–>128	128	128	-
PTSO	4–32	16	32	4–128	32	64	-

MIC: minimum inhibitory concentration. MFC: minimum fungicidal concentration.