Table 3.
MIC data by reference methods for 938 isolates of Candida auris and new and established agents.
| No. isolates | Antifungal Agent, MIC Ranges (Mode or MIC90) | Ref | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMB | FLU | VOR | ITZ | ISA | POS | AND | MCF | RZF | IBX | MGX | VT-1598 | ||
| 123 | 0.12–8 (0.5) | 4–>64 (>64)* | 0.03–16 (2)* | 0.03–2 (0.12)* | 0.01–4 (0.25)* | 0.01–8 (0.01)* | 0.01–8 (0.12) | 0.01–8 (0.12) | [28] | ||||
| 350 | 0.12–8 (1) | 1–>64 (>64) | 0.03–16 (0.12) | 0.03–16 (0.12) | <0.01–4 (0.03)* | <0.1–8 (<0.01)* | 0.016–8 (0.5) | 0.016–16 (0.12) | [29] | ||||
| 73 | 0.06–2 (0.25) | >64 (>64) | 0.5–>8 (4) | 0.06-0.5(0.25) | 0.03–2 (0.12) | 0.03–0.12 (0.12) | 0.01–0.5 (0.06) | 0.03–0.12 (0.06) | [30] (EUCAST) | ||||
| 122 | 0.5–1 (1) | 0.5–>64 (>64) | 0.01–>32 (0.06) | 0.03–>32 (0.12) | 0.06–16 (0.25) | [17] (EUCAST) | |||||||
| 19 | 0.12–1 (1) | 0.5–32 (>32) | 0.03–0.5 (0.03) | 0.06–2 (0.25) | 0.03–0.25 (0.12)* | [18] | |||||||
| 122,122 | 0.5–1 (1) | 0.5–>64 (>64) | <0.01–4 (BM)* | NA | <0.01–2 (BM)* | NA | 0.01–>32 (0.06) | 0.03–>32 (0.12) | 0.06–2 (0.5) | <0.01–0.12 (<0.01) | [13,16] (EUCAST) | ||
| 27 | 0.5–4 | 8–>64 | 0.25–>16 | 0.06–>8 | <0.01 | [31] | |||||||
| 16 | 0.5–8 (4) | 1–64 (>64) | <0.01–1 (1) | <0.01–1 (1) | 0.25–1 (1) | 0.12–0.25 (0.25) | 0.25–2 (2) | <0.01–0.06 (0.03) | [32] | ||||
| 13 | 2–>64 (>64) | <0.01–0.03 (0.12) | [33] | ||||||||||
| 100 | 0.03–>8 (0.25) | [34] | |||||||||||
AMB, amphotericin B; FLU, fluconazole; VOR, voriconazole; ITZ, itraconazole; ISA, isavuconazole; POS, posaconazole; AND, anidulafungin; MCF, micafungin; RZF, rezafungin; IBX, ibrexafungerp; MGX, manogepix; VT-1598. MICs were determined by CLSI or EUCAST broth microdilution methods [6,7]. NA: not available. Mode: most frequent MIC in the distribution; MIC90: value at which 90% of the isolates were inhibited. *MIC distribution having more than one mode. Reference [29], multi-drug resistant isolates; references [32] and [35] provided in vivo data.