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Permeability of RhB cargo encapsulated in non-targeted (DON-SLN) or ApoE-targeted SLNs (APOE-DON-SLN) across the BBB model (10 µg/mL concentration, 2 h). Values presented are means ± SEM. Statistical analysis: one-way ANOVA followed by Dunnett’s posttest, where **** p < 0.0001, compared to the DON-SLN group; n = 4. Papp: apparent permeability coefficient, SF: sodium fluorescein (376 Da), EBA: Evans blue-labeled bovine serum albumin (67 kDa).
