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. 2020 Dec 29;10(1):38. doi: 10.3390/cells10010038

Figure 1.

Figure 1

NPTX2 levels and relation to biomarkers in CSF. (A): Levels of NPTX2 in CSF of SCD subjects and DLB and AD patients. Box-plots are median and interquartile ranges, whiskers are 95% percentiles. When significant, the p-value of Kruskal–Wallis with post-test is indicated. (B): 3D plot of the levels of the three related synaptic markers, NPTX2, VGF, α-synuclein. All levels were Ln transformed. (C): Pearson r values for correlations between the three transformed marker levels for each diagnostic group independently. In the bottom table, the Pearson r values for the correlation to AD biomarkers and age are given. Color intensity indicates the strength of the correlation, with blue being stronger positive correlations and red stronger negative correlations. (D): ROC curve distinguishing between SCD and DLB. For all models, age was included. Markers combined is a model using NPTX2, VGF, and α-synuclein combined. AUCs and a significance value indicating if the significantly deviate for 0.5 are given.