Table 1.
An overview of the studied population. Levels of all parameters used in this study are represented either as mean (SD) or as median with upper and lower 95% confidence intervals. Cognitive scores are given as z-scores except for the MMSE. Levels and numbers of n are indicated per diagnostic subgroup. For each subgroup, the p-value of the F-test from a Kruskal–Wallis is indicated and when significant, an adjust p-value of the post-test. Significant values are indicated by a bold, underlined, and italic font.
| SCD n = 27 | DLB n = 48 | AD n = 20 | p-Value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | n(%) | Mean (SD) | n(%) | Mean (SD) | n(%) | F-Test | SCD-DLB | SCD-AD | DLB-AD | |
| Female % | 4(15) | 6 (13) | 2 (10) | |||||||
| Age | 63.7 (5.9) | 67.7 (6.4) | 65.3 (6.0) | 0.018 | 0.015 | 0.827 | 0.560 | |||
| Education | 5.7 (1.0) | 5.1 (1.3) | 5.3 (1.0) | 0.138 | N.R. | N.R. | N.R. | |||
| Global | −0.21 (0.53) | 21 | −2.48 (1.16) | 40 | −4.00 (2.03) | 17 | <0.001 | <0.001 | <0.001 | 0.139 |
| Memory | −0.15 (0.8) | 21 | −2.76 (1.7) | 40 | −2.99 (1.95) | 13 | <0.001 | <0.001 | <0.001 | 1.000 |
| Attention | −0.28 (0.71) | 21 | −2.86 (2.15) | 40 | −3.63 (2.48) | 13 | <0.001 | <0.001 | <0.001 | 1.000 |
| Executive function | −0.23 (0.73) | 21 | −2.49 (1.29) | 40 | −3.08 (1.35) | 13 | <0.001 | <0.001 | <0.001 | 0.792 |
| Language | −0.13 (0.61) | 21 | −1.14 (0.68) | 40 | −1.99 (1.74) | 12 | <0.001 | <0.001 | <0.001 | 0.780 |
| Visual spatial | −0.21 (0.89) | 14 | −2.22 (1.85) | 30 | −4.79 (3.27) | 10 | <0.001 | 0.003 | <0.001 | 0.166 |
| MMSE | 28.12 (2.02) | 18 | 23.07 (4.40) | 42 | 18.67 (542.) | 18 | <0.001 | <0.001 | <0.001 | 0.048 |
| Median [95%interval], n | Median [95%interval], n | Median [95%interval], n | F-test | SCD-DLB | SCD-AD | DLB-AD | ||||
| Aβ1–42 (pg/mL) | 1032 [982–1112], 26 | 788 [760–905], 47 | 586 [531–614], 19 | <0.001 | 0.002 | <0.001 | <0.001 | |||
| T-Tau (pg/mL) | 199 [182–237], 26 | 299 [285–393],48 | 596 [522–949], 19 | <0.001 | 0.003 | <0.001 | <0.001 | |||
| p-Tau (pg/mL) | 41.0 [34.7–42.8], 26 | 47.0 [43.4–58.6], 47 | 87.5 [77.6–120.7], 20 | <0.001 | 0.101 | <0.001 | <0.001 | |||
| NPTX2 (pg/mL) | 773 [581–1123], 27 | 474 [279–659], 48 | 453 [317–696], 20 | <0.001 | <0.001 | 0.009 | 1.000 | |||
| α-synuclein (pg/mL) | 1508 [1281–1971], 22 | 1811 [1537–2299], 44 | 2009 [1764–2658], 19 | 0.004 | 0.156 | 0.003 | 0.166 | |||
| VGF (pmol/mL) | 3.66 [2.97–5.15], 22 | 2.58 [2.04–3.42] 44 | 3.33 [2.40–4.41] 20 | 0.007 | 0.009 | 1.000 | 0.136 | |||