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. 2020 Dec 31;14(1):30. doi: 10.3390/ph14010030

Figure 7.

Figure 7

Inhibitory effect of PD0325901 on paclitaxel-induced cold and mechanical allodynia in mice. Paclitaxel (6 mg/kg, i.p.) was administered on days 0 and 7, and PD0325901 (30 mg/kg, p.o.) was administered daily from days 0 to 14. (A) Withdrawal latencies, presented as means ± standard deviations (S.D.), represent the time taken by mice to withdraw their hind paws following cold stimulation (10 °C) (n = 7 per group). ** p < 0.01 vs. vehicles (Shapiro–Wilk test and Kruskal–Wallis test followed by the Scheffe test). (B–D) The number of paw lifts elicited by five mechanical stimulations using von Frey filaments corresponding to (B) innocuous (0.16 g), (C) intermediate (0.4 g), and (D) noxious (1.4 g) bending forces. The aversive response score was calculated based on two paw lifts (n = 7 per group). ** p < 0.01 vs. vehicles (Shapiro-Wilk test and one-way analysis of variance (ANOVA) with Tukey test).