Table 1.

Limit of detection LoD of EndoPep-MS in samples spiked with BoNT/C and BoNT/D reference toxins.

BoNT	Matrix	Biological Replicates
		1	2	3
		LoD (mLD50/500 µL)	LoD (mLD50/500 µL)	LoD (mLD50/500 µL)
C	Water	1	2	2
	Sera	2	1	2
	Broth culture	2	2	1
	Feces	N/A	N/A	N/A
D	Water	1	0.5	0.5
	Sera	0.5	0.5	0.25
	Broth culture	2	1	2
	Feces	2	1	2

N/A: not applicable.