Table 5.
Specialized metabolites biosynthetic gene clusters (BGCs) from the nine cyanobacterial strains isolated from Balaruc’s thermal mud. Automatic annotations have been performed using the MicroScope platform (computing AntiSMASH and MIBiG softwares). * Some clusters have been predicted at the end/start of a contig and are questionable regarding their completeness.
| Genus/Species | Strain | Nb of Clusters Predicted | Identified Clusters | Reported Activity | Unknown/Homologous Cluster | Unknown/Unknown Cluster |
|---|---|---|---|---|---|---|
| P. raciborskii | PMC 877.14 | 7 | Phytoene or derivative | Antioxidant | 1 | 5 |
| Laspinema sp. | PMC 878.14 | 7 | Phytoene or derivative Heterocyclic cyanobactin |
Antioxidant Cytotoxic |
5 | 0 |
| M. vaginatus | PMC 879.14 | 7 | Phytoene or derivative | Antioxidant | 3 | 3 |
| L. martensiana | PMC 880.14 | 9 | Phytoene or derivative Squalene Schizokinen-like |
Antioxidant Antioxidant Iron-chelating activity |
5 | 1 |
| Nostoc sp. | PMC 881.14 | 20 * | Phytoene or derivative (2×) Heterocyst glycolipid |
Antioxidant n.d. |
7 | 10 |
| Aliinostoc sp. | PMC 882.14 | 21 | Shinorine-like Microginin-like Amycomicin-like Phytoene or derivative (2×) Heterocyst glycolipid Microviridin-like |
Antioxidant ACE inhibition; no cytotoxic Antibiotic Antioxidant n.d. Protease inhibitor |
6 | 8 |
| L. boryana | PMC 883.14 | 16 | Phytoene or derivative (5×) | Antioxidant | 8 | 3 |
| Calothrix sp. | PMC 884.14 | 27 | Cyanobactin Mycosporine-glycine-like Cylindrocyclophane-like Phytoene/Lycopene or derivative (3×) Heterocyst glycolipid |
Cytotoxic Antioxidant Cytotoxic; antibacterial Antioxidant n.d. |
14 | 6 |
| P. couteii | PMC 885.14 | 10 | Phytoene or derivative (2×) | Antioxidant | 2 | 6 |
| Total | 124 | 31 | 51 | 42 |