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. 2021 Jan 5;10(1):72. doi: 10.3390/cells10010072

Table 4.

Classification of astrocyte types I–IV—subcellular distribution, morphology, number, and size of Rab6A+ grains within the individual cell.

Type Morphology, Number, and Size of Rab6A+ Grains Subcellular Distribution
I
  • -

    evenly sized

  • -

    mean area: 2.5 µm2

  • -

    mean number *: 123
  • -

    evenly distributed all over the cell

  • -

    present in perinuclear cytoplasm, stem processes, PAPs

  • -

    at the cell boundary, throughout the glial territory
II
  • -

    heterogeneous size

  • -

    mean area: 3.0 µm2

  • -

    mean number *: 104
  • -

    partly appearing in clusters

  • -

    present in perinuclear cytoplasm, stem processes, PAPs

  • -

    at the cell boundary, throughout the glial territory
III
  • -

    size of grains in perinuclear cytoplasm or at the cell boundary may be double or multiple of those nearby

  • -

    evenly sized in stem processes, PAPs

  • -

    mean area: 2.6 µm2

  • -

    mean number *: 70
  • -

    uneven distribution in perinuclear cytoplasm and at cell boundary

  • -

    evenly distributed in stem processes and PAPs

  • -

    may be only sparsely present in processes
IV
  • -

    large size, lumps

  • -

    mean area: 4.3 µm2

  • -

    mean number *: 9
  • -

    organized in cluster(s) on one side of nucleus

  • -

    sparsely present if at all, in stem processes and PAPs, thus hardly present throughout the glial territory

* number of Rab6A+ puncta/ROI (see Figure S10).