Table 2.
Associations between 12 previously reported genetic variants and RPL in the REPLIK study.
| Locus Name | Chr: Position | Variant ID | EA/NEA | EAF Cases/Controls | N Cases/N Controls | EAE | OR (95% CI) | p-Value |
|---|---|---|---|---|---|---|---|---|
| F2 | 11:46761055 | rs1799963 | A/G | 0.018/0.011 | 110/46 | 0.49 | 1.64 (0.23, 32.48) |
0.66 |
| F5 | 1:169519049 | rs6025 | A/G | 0.018/0.022 | 114/46 | −0.22 | 0.80 (0.15, 5.92) |
0.80 |
| F7 | 13:113773159 | rs6046 | G/A | 0.89/0.85 | 75/46 | 0.34 | 1.40 (0.65, 3.04) |
0.38 |
| GP1A | 5:52347369 | rs1126643 | C/T | 0.63/0.54 | 81/46 | 0.35 | 1.43 (0.85, 2.44) |
0.18 |
| ESR1 | 6:152163335 | rs2234693 | T/C | 0.49/0.55 | 110/106 | −0.18 | 0.84 (0.57, 1.23) |
0.37 |
| ADRB2 | 5:148206473 | rs1042714 | C/G | 0.60/0.51 | 81/46 | 0.38 | 1.47 (0.86, 2.56) |
0.16 |
| ENOS | 15:35147732-35262040 | Intron-4 ǂ VNTR | B/A | 0.83/0.80 | 102/46 | 0.15 | 1.16 (0.63, 2.08) |
0.63 |
| ACE | 17:61565890 | rs1799752 † | D/I | 0.52/0.53 | 100/46 | −0.048 | 0.95 (0.59, 1.54) |
0.85 |
| MTHFR | 1:11856378 | rs1801133 | T/C | 0.30/0.24 | 114/46 | 0.33 | 1.40 (0.80, 2.51) |
0.25 |
| IL6 | 7:22766840 | 14718 | G/C | 0.59/0.56 | 106/106 | 0.11 | 1.10 (0.77, 1.64) |
0.57 |
| IL8 | 4:74607055 | rs2227306 | T/C | 0.40/0.37 | 114/106 | 0.11 | 1.10 (0.76, 1.64) |
0.60 |
| IL10 | 1:206946897 | rs1800896 | A/G | 0.59/0.49 | 114/106 | 0.47 | 1.60 (1.07, 2.42) |
0.025 |
| GRS | 114/106 | 1.56 (1.21, 2.04) |
8.7 × 10−4 |
Legend: † Indel; ǂ Tandem repeat; EA/NEA: Risk allele/Alternate allele; EAF: Effect allele frequency; EAE: Estimated allelic effect (beta); GRS, genetic risk score.