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Antileishmanial activity on intramacrophage amastigotes of L. infantum and evaluation of selectivity toward THP-1 cultures.
|
L. infantum Amastigotes IC50 (μM) 1 |
S.I. 2 | |
|---|---|---|
| 1 | 0.19 ± 0.11 | 11 |
| 3 | 0.13 ± 0.09 | 21 |
| 5 | 0.52 ± 0.28 | 3.6 |
| 6 | 0.66 ± 0.06 | 1.3 |
| AMP | 0.18 ± 0.03 | >109 |
1 Reported data are the mean of three experiments. Amphotericin B was used as reference drug; 2 Selectivity index: ratio between compounds’ IC50s on THP-1 cell line (Table 1) and toward L. infantum amastigotes.
