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. 2021 Jan 5;11(1):55. doi: 10.3390/brainsci11010055

Table 1.

Results of linear regression analyses of regional cortical thickness (rCTh) values by age in healthy subjects.

ROIs Left Hemisphere (N = 120) Right Hemisphere (N = 120)
r p Intercept Slope Variation α r p Intercept Slope Variation α
Mean SE Mean (×10−2) SE (×10−2) % Per Decade Mean SE Mean (×10−2) SE (×10−2) % Per Decade
Frontal
Caudal anterior cingulate −0.292 * 0.0012 2.991 0.090 −0.643 0.194 −2.206 −0.242 * 0.0077 2.767 0.068 −0.399 0.147 −1.457
Caudal middle frontal −0.448 ** 0.0000 2.945 0.037 −0.432 0.080 −1.483 −0.428 ** 0.0000 3.001 0.040 −0.438 0.085 −1.475
Lateral orbitofrontal −0.441 ** 0.0000 3.277 0.043 −0.497 0.093 −1.535 −0.444 ** 0.0000 3.145 0.039 −0.448 0.083 −1.439
Medial orbitofrontal −0.343 ** 0.0001 2.751 0.039 −0.332 0.084 −1.213 −0.393 ** 0.0000 2.761 0.035 −0.346 0.075 −1.261
Paracentral −0.479 ** 0.0000 2.664 0.037 −0.467 0.079 −1.783 −0.452 ** 0.0000 2.694 0.036 −0.431 0.078 −1.622
Pars opercularis −0.496 ** 0.0000 3.147 0.039 −0.524 0.084 −1.691 −0.346 ** 0.0001 3.090 0.046 −0.396 0.099 −1.291
Pars orbitalis −0.417 ** 0.0000 3.393 0.050 −0.542 0.109 −1.620 −0.398 ** 0.0000 3.328 0.048 −0.492 0.104 −1.495
Pars triangularis −0.464 ** 0.0000 3.106 0.042 −0.521 0.091 −1.704 −0.516 ** 0.0000 3.091 0.040 −0.566 0.086 −1.866
Precentral −0.631 ** 0.0000 2.912 0.037 −0.700 0.079 −2.481 −0.505 ** 0.0000 2.892 0.037 −0.507 0.080 −1.784
Rostral anterior cingulate −0.311 ** 0.0005 3.091 0.056 −0.430 0.121 −1.404 −0.21 6* 0.0176 3.035 0.066 −0.343 0.142 −1.134
Rostral middle frontal −0.448 ** 0.0000 2.878 0.031 −0.363 0.067 −1.270 −0.510 ** 0.0000 2.915 0.030 −0.417 0.065 −1.445
Superior frontal −0.583 ** 0.0000 3.223 0.035 −0.588 0.075 −1.859 −0.576 ** 0.0000 3.263 0.036 −0.598 0.078 −1.868
Frontal pole −0.228 * 0.0123 3.169 0.070 −0.385 0.151 −1.222 −0.157 0.0856
Occipital
Cuneus −0.377 ** 0.0000 2.213 0.037 −0.352 0.080 −1.613 −0.319 ** 0.0004 2.191 0.042 −0.328 0.090 −1.515
Lateral occipital −0.265 * 0.0035 2.462 0.041 −0.266 0.089 −1.083 −0.205 * 0.0250 2.378 0.043 −0.210 0.093 −0.882
Lingual −0.545 ** 0.0000 2.359 0.032 −0.488 0.069 −2.120 −0.459 ** 0.0000 2.296 0.034 −0.414 0.074 −1.837
Pericalcarine −0.488 ** 0.0000 2.048 0.040 −0.526 0.087 −2.661 −0.397 ** 0.0000 2.017 0.041 −0.412 0.088 −2.091
Parietal
Inferior parietal −0.309 ** 0.0006 2.771 0.035 −0.266 0.075 −0.960 −0.294 * 0.0011 2.761 0.037 −0.265 0.079 −0.960
Isthmus cingulate −0.233 * 0.0103 2.572 0.061 −0.344 0.132 −1.348 −0.224 * 0.0138 2.721 0.056 −0.300 0.120 −1.106
Postcentral −0.594 ** 0.0000 2.504 0.033 −0.573 0.071 −2.356 −0.518 ** 0.0000 2.589 0.034 −0.489 0.074 −1.927
Posterior cingulate −0.409 ** 0.0000 2.658 0.040 −0.415 0.085 −1.582 −0.393 ** 0.0000 2.599 0.032 −0.316 0.068 −1.223
Precuneus −0.279 * 0.0020 2.654 0.039 −0.262 0.083 −0.988 −0.324 ** 0.0003 2.654 0.034 −0.275 0.074 −1.038
Superior parietal −0.328 ** 0.0003 2.445 0.028 −0.225 0.060 −0.920 −0.332 ** 0.0002 2.493 0.031 −0.254 0.067 −1.020
Supramarginal −0.462 ** 0.0000 2.856 0.038 −0.458 0.081 −1.626 −0.374 ** 0.0000 2.898 0.038 −0.355 0.081 −1.232
Temporal
Banks sts −0.317 ** 0.0004 2.905 0.048 −0.378 0.104 −1.311 −0.166 0.0702
Entorhinal −0.305 * 0.0007 4.462 0.120 −0.901 0.259 −2.066 −0.203 * 0.0259 4.231 0.134 −0.651 0.288 −1.558
Fusiform −0.425 ** 0.0000 3.098 0.046 −0.504 0.099 −1.651 −0.500 ** 0.0000 3.133 0.039 −0.528 0.084 −1.712
Inferior temporal −0.346 ** 0.0001 3.272 0.045 −0.392 0.098 −1.204 −0.344 ** 0.0001 3.269 0.043 −0.368 0.092 −1.130
Middle temporal −0.532 ** 0.0000 3.526 0.042 −0.623 0.091 −1.798 −0.476 ** 0.0000 3.492 0.043 −0.542 0.092 −1.572
Parahippocampal −0.325 ** 0.0003 2.927 0.050 −0.403 0.108 −1.390 −0.234 * 0.0100 2.880 0.064 −0.360 0.138 −1.258
Superior temporal −0.511 ** 0.0000 3.309 0.046 −0.639 0.099 −1.972 −0.447 ** 0.0000 3.374 0.053 −0.615 0.113 −1.857
Temporal pole −0.264 * 0.0035 4.474 0.109 −0.702 0.236 −1.590 −0.027 0.7686
Transverse temporal −0.609 ** 0.0000 2.840 0.055 −0.992 0.119 −3.694 −0.615 ** 0.0000 2.931 0.058 −1.053 0.124 −3.809
Insula −0.055 0.5500 −0.125 0.1727

ROIs: regions of interest, defined according to the Desikan-Killiany atlas (Desikan et al., 2006). r: Pearson’s coefficient. SE: Standard Error. ** showing significant linear correlation (p < 0.0007, Bonferroni corrected significance level). * Not significant but showing a tendency of age dependence (0.0007 < p < 0.05). α Ratio of the values at age 21.