Table 6.
MicroRNA regulating natural products.
| Classification | Compound/Extract | Source | Cell Line/ Animal Model |
Dose/Duration | Efficacy | Mechanism | Reference |
|---|---|---|---|---|---|---|---|
| Plant | 1′S-1′-acetoxychavicol acetate | Alpinia conchigera | SiHa, CaSki | 20, 30 µM; 6, 12 h | Induction of apoptosis Inhibition of proliferation |
↑ SMAD4 ↓ miR-210 |
[20] |
| Plant | 1′S-1′-acetoxychavicol acetate | Alpinia conchigera | SiHa, CaSki | 20, 30 µM; 6, 12, 48 h | Induction of apoptosis Inhibition of proliferation |
↑ caspase-3, -8 ↓ miR-629 |
[48] |
Mothers against decapentaplegic homolog 4 (SMAD4).