Table 3.
Factors that contributed to non-e-curative outcome in patients with early gastric cancers after ESD
| Clinico-pathologic parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Age (in years) | 1.05 (1.00–1.09) | 0.049 | 1.08 (1.01–1.17) | 0.029 |
| Tumor location | ||||
| Lower one third | 1 (Reference) | 1 (Reference) | ||
| Middle or Upper third | 4.55 (2.04–10.12) | < 0.001 | 5.46 (1.65–18.12) | 0.006 |
| Gross tumor type | ||||
| Group 1 | 1 (Reference) | 1 (Reference) | ||
| Group 2 | 5.70 (1.65–19.65) | 0.006 | 9.77 (1.23–77.65) | 0.031 |
| Ulceration status | ||||
| Absent | 1 (Reference) | 1 (Reference) | ||
| Present | 3.03 (1.25–7.31) | 0.014 | 2.39 (0.59–9.65) | 0.223 |
| Size of tumor | ||||
| ≤ 2 cm | 1 (Reference) | 1 (Reference) | ||
| > 2 cm | 6.19 (2.79–13.77) | < 0.001 | 7.63 (2.29–25.42) | 0.001 |
| Differentiation | ||||
| Differentiated | 1 (Reference) | 1 (Reference) | ||
| Undifferentiated | 16.43 (6.60–40.89) | < 0.001 | 15.54 (1.65–146.22) | 0.016 |
| Lauren’s category | ||||
| Intestinal | 1 (Reference) | 1 (Reference) | ||
| Non-intestinal | 16.43 (6.60–40.89) | < 0.001 | 3.29 (0.36–31.40) | 0.300 |
ESD Endoscopic Submucosal Dissection, OR Odds Ratio, CI Confidence Interval, Group 1 = lesions with Protruding (0-I), Purely superficial flat (0-IIb) and Mixed variants with 0-IIb predominant, Group2 = Purely superficial elevated (0-IIa) or depressed (0-IIc) or mixed variants with either 0-IIa or 0-IIc predominant