Table 5.
Risk factors for submucosal invasion in patients with early gastric cancer following Endoscopic Submucosal Dissection
| Clinico-pathologic parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Tumor location | ||||
| Lower one third | 1 (Reference) | 1 (Reference) | ||
| Middle or Upper third | 8.28 (3.15–21.75) | < 0.001 | 8.88 (2.90–27.17) | < 0.001 |
| Gross tumor type | ||||
| Group 1 | 1 (Reference) | 1 (Reference) | ||
| Group 2 | 4.35 (1.25–15.13) | 0.021 | 3.59 (0.84–15.45) | 0.086 |
| Ulceration status | ||||
| Absent | 1 (Reference) | 1 (Reference) | ||
| Present | 4.20 (1.69–10.41) | 0.002 | 3.70 (1.15–11.90) | 0.028 |
| Size of tumor | ||||
| ≤ 2 cm | 1 (Reference) | 1 (Reference) | ||
| > 2 cm | 3.77 (1.66–8.57) | 0.002 | 2.94 (1.08–8.02) | 0.036 |
| Differentiation | ||||
| Differentiated | 1 (Reference) | 1 (Reference) | ||
| Undifferentiated | 6.33 (2.65–15.14) | < 0.001 | 6.51 (2.23–18.98) | 0.001 |
OR Odds Ratio, CI Confidence Interval, Group 1 = lesions with Protruding (0-I), Purely superficial flat (0-IIb) and Mixed variants with 0-IIb predominant, Group2 = Purely superficial elevated (0-IIa) or depressed (0-IIc) or mixed variants with either 0-IIa or 0-IIc predominant