Table 3.
Results of multivariate Cox analyses of clinical and molecular variables
| Criteria | PFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | p | |
| FIGO I/II versus III/IV (n = 19 vs 158) | 5.029 | 2.029–12.46 | 0.001 | 2.08 | 0.998–4.333 | 0.051 |
| Resection R0 versus R1/2 (n = 41 vs 136) | 1.865 | 1.257–2.766 | 0.002 | 2.453 | 1.591–3.781 | 0.001 |
| CAMK2N1 U versus M (n = 162 vs 15) | 1.408 | 0.789–2.512 | 0.246 | 1.300 | 0.670–2.524 | 0.438 |
| KRT86 U versus M (n = 138 vs 39) | 1.477 | 0.992–2.201 | 0.055 | 1.243 | 0.787–1.964 | 0.351 |
| CAMK2N1/KRT86 U versus M (n = 129 vs 48) | 1.416 | 0.965–2.077 | 0.075 | 1.214 | 0.788–1.871 | 0.379 |
| CAMK2N1/RUNX3 U versus M (n = 147 vs 32) | 1.587 | 1.031–2.442 | 0.036 | 1.602 | 1.017–2.542 | 0.042 |
| CAMK2N1/KRT86/RUNX3 U versus M (n = 119 vs 58) | 1.543 | 1.070–2.223 | 0.020 | 1.348 | 0.903–2.012 | 0.144 |
Analyses included clinical variables and one of the molecular markers. Data for clinical variables are exemplarily and result from the analysis with CAMK2N1/RUNX3. LogRank test results with significance are marked in bold. U, unmethylated; M, methylated. Marker combinations are positive (methylated) if at least one single marker is methylated (<OR> combinations) otherwise the combination is scored as unmethylated