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. 2021 Jan 22;21:72. doi: 10.1186/s12935-021-01762-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Identification of 19 hub genes from the interaction network. a A PPI network of the 95 candidate genes consists of 67 nodes and 358 edges. The node size varies from small to large according to the number of neighbored genes. b A subnetwork consists of 19 nodes and 166 edges extracted from (a) with the MCODE clustering algorithm. PPI protein-protein interaction. c Volcano plot showing the 19 hub genes in TCGA-LIHC (left) and GSE14520 (right) datasets