Table 3.
Reference intervals for leukocyte indices in healthy mice of mixed breeds
| Leukogram | ||||||||
|---|---|---|---|---|---|---|---|---|
| Parameters (Unit) | SWISS (mean ± SD) | BALB/c (mean ± SD) | C57BL/6 (mean ± SD) | B6D2F1 (mean ± SD) | ||||
| Male | Female | Male | Female | Male | Female | Male | Female | |
| Global leucometry | ||||||||
| WBC (×103/µL) | 4.98 ± 1.26 | 5.16 ± 1.02 | 5.36 ± 0.96 | 6.23 ± 2.57 | 5.80 ± 0.34 | 4.24 ± 0.74 | 3.84 ± 0.23 | 5.99 ± 0.48 |
| W‐SCR (%) | 83.43 ± 1.28 | 92.46 ± 6.22 | 75.66 ± 6.37 | 66.58 ± 26.19 | 84.95 ± 7.04 | 80.01 ± 5.79 | 81.59 ± 6.04 | 85.89 ± 4.21 |
| W‐MCR (%) | 12.46 ± 1.12 | 13.15 ± 1.88 | 17.33 ± 1.99 | 13.29 ± 6.69 | 13.25 ± 1.16 | 13.94 ± 1.56 | 14.30 ± 3.81 | 10.26 ± 2.61 |
| W‐LCR (%) | 4.45 ± 1.04 | 4.82 ± 1.41 | 7.37 ± 3.24 | 5.55 ± 1.55 | 5.08 ± 0.44 | 6.74 ± 1.05 | 4.14 ± 2.27 | 3.73 ± 1.61 |
| W‐SCC (×102/µL) | 6.57 ± 0.97 | 5.59 ± 0.75 | 3.88 ± 1.02 | 3.59 ± 0.76 | 5.25 ± 0.50 | 4.16 ± 0.39 | 3.19 ± 0.40 | 5.13 ± 0.15 |
| W‐MCC (×102/µL) | 1.01 ± 0.18 | 1.24 ± 0.37 | 1.01 ± 0.35 | 0.85 ± 0.19 | 0.75 ± 0.15 | 0.80 ± 0.10 | 0.59 ± 0.11 | 0.69 ± 0.19 |
| W‐LCC (×102/µL) | 0.39 ± 0.11 | 0.50 ± 0.19 | 0.46 ± 0.21 | 0.43 ± 0.11 | 0.29 ± 0.08 | 0.40 ± 0.09 | — | — |
| Differential leucometry | ||||||||
| LYM (×102/µL) | 7.65 ± 0.63 | 6.86 ± 0.97 | 6.60 ± 0.64 | 7.27 ± 0.85 | 7.28 ± 0.55 | 5.02 ± 0.33 | 7.45 ± 0.63 | 7.99 ± 0.19 |
| MON (×102/µL) | 2.72 ± 0.73 | 3.10 ± 0.87 | 2.52 ± 1.29 | 2.98 ± 1.79 | 2.30 ± 0.57 | 1.99 ± 0.50 | 3.29 ± 0.31 | 3.10 ± 0.29 |
| EOS (×102/µL) | 1.15 ± 0.55 | 1.39 ± 0.34 | 1.49 ± 0.94 | 1.88 ± 0.98 | 2.18 ± 0.70 | 4.19 ± 0.83 | 1.99 ± 0.31 | 1.30 ± 0.29 |
| NEU/SEG (×102/µL) | 1.39 ± 0.34 | 1.69 ± 0.27 | 3.25 ± 0.57 | 2.16 ± 0.64 | 2.73 ± 0.41 | 2.12 ± 0.45 | 1.62 ± 0.40 | 1.59 ± 0.11 |
CBCs were performed in an automated veterinary hematology counter pocH‐100iV Diff™ (Sysmex® ‐ Roche). Data show means ± standard deviation (SD), calculated with GraphPad Prism version 6.01.
Abbreviations: —, absence of data; BAS, basophiles cells; EOS, eosinophils; LYM, lymphocytes; MON, monocytes; NEU/BAN, absence of immature neutrophils (bands); NEU/SEG, neutrophils/Segmented; WBC, number of white blood cells; W‐LCC, NEU, number of large white blood cells, gametocyte; W‐LCR, percent ratio of large white blood cell; W‐MCC, MON, number of middle white blood cells, monocyte; W‐MCR, percent ratio of middle white blood cell; W‐SCC, LYN, number of small white blood cells, lymphocyte; W‐SCR, percent ratio of small white blood cell.