Table 4.
Reference intervals for serum biochemical indices in healthy mice of mixed breeds
| Serum biochemistry | ||||||||
|---|---|---|---|---|---|---|---|---|
| Parameters (Unit) | SWISS (mean ± SD) | BALB/c (mean ± SD) | C57BL/6 (mean ± SD) | B6D2F1 (mean ± SD) | ||||
| Male | Female | Male | Female | Male | Female | Male | Female | |
| UR (mg/dL) | 60.54 ± 6.46 | 40.69 ± 4.63 | 40.48 ± 3.91 | 36.24 ± 3.42 | 57.66 ± 3.16 | 60.15 ± 6.95 | 58.51 ± 10.18 | 39.29 ± 1.48 |
| ALT (UI/L) | 46.15 ± 5.62 | 59.03 ± 9.58 | 99.44 ± 39.61 | 239.50 ± 141.20 | 76.37 ± 20.26 | 110.00 ± 16.83 | 65.72 ± 6.95 | 73.79 ± 9.46 |
| AST (UI/L) | 121.60 ± 35.93 | 163.60 ± 48.13 | 135.20 ± 26.53 | 156.70 ± 57.20 | 136.70 ± 34.86 | 293.40 ± 62.65 | 90.09 ± 8.12 | 95.23 ± 16.25 |
| AP (UI/L) | 169.20 ± 32.56 | 147.30 ± 23.58 | 209.10 ± 36.21 | 362.90 ± 226.60 | 97.29 ± 9.58 | 106.00 ± 16.83 | 249.80 ± 6.28 | 119.00 ± 8.27 |
| TP (g/dL) | 5.31 ± 0.31 | 5.14 ± 0.47 | 5.21 ± 0.46 | 5.23 ± 1.68 | 8.03 ± 0.34 | 7.85 ± 0.62 | 4.42 ± 0.17 | 5.60 ± 0.53 |
| ALB (g/dL) | 2.77 ± 0.17 | 1.84 ± 0.37 | 2.40 ± 0.47 | 1.74 ± 0.50 | 2.35 ± 0.12 | 2.10 ± 0.47 | 2.29 ± 0.12 | 2.33 ± 0.06 |
| GLB (g/dL) | 2.60 ± 0.23 | 3.34 ± 0.28 | 2.77 ± 0.23 | 3.50 ± 1.89 | 5.80 ± 0.31 | 5.94 ± 0.40 | 2.19 ± 0.08 | 3.30 ± 0.56 |
| UA (mg/dL) | 2.32 ± 0.28 | 1.32 ± 0.20 | 2.19 ± 0.24 | 2.55 ± 0.24 | 2.67 ± 0.61 | 1.09 ± 0.10 | 1.89 ± 0.21 | 1.43 ± 0.16 |
| CHL (mg/dL) | 90.20 ± 6.13 | 91.81 ± 8.51 | 129.10 ± 11.82 | 77.72 ± 30.33 | 77.73 ± 3.22 | 44.92 ± 6.18 | 102.00 ± 6.64 | 66.03 ± 5.32 |
| TG (mg/dL) | 140.40 ± 15.36 | 94.02 ± 3.29 | 76.89 ± 22.42 | 68.11 ± 34.57 | 31.56 ± 2.12 | 31.56 ± 2.42 | 214.40 ± 12.49 | 187.80 ± 11.52 |
| GLC (mg/dL) | 147.60 ± 31.76 | 214.40 ± 47.29 | 160.40 ± 26.21 | 141.90 ± 30.47 | 233.20 ± 4.65 | 208.80 ± 6.95 | 239.80 ± 22.13 | 242.40 ± 9.62 |
The Creatinine (CR) showed values below the detection limits (<0.2 mg/dL). Blood sera were processed at VITROS® 350 (Ortho Clinical Diagnostics ‐ Johnson & Johnson) automated spectrophotometer. The Mean and Standard Deviation (SD), calculated through GraphPad Prism version 6.01.
Abbreviations: ALB, albumin; ALT, alanine transaminase; AP, alkaline phosphatase; AST, aspartate transaminase; CHL, cholesterol; GLB, globulin; GLC, glucose; TG, triglycerides; TP, total protein; UA, uric acid; UR, urea.