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. 2020 Sep 25;178(2):375–390. doi: 10.1093/toxsci/kfaa146

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Published by Oxford University Press on behalf of the Society of Toxicology 2020.

This work is written by US Government employees and is in the public domain in the US.

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Figure 6. — Biological functions and disease categories enriched in the lungs of the tobacco smoke (TS)-, crystalline silica (CS)-, and TS plus CS-exposed rats. Enrichment analysis of the significantly differentially expressed genes (SDEGs) detected by NGS analysis of the gene expression data was performed by Ingenuity Pathway Analysis (IPA) as described in the text. Eleven of the top-ranking-enriched biological function and disease categories, compared with the control, are presented. In the TS versus Air group of rats, the number of SDEGs belonging to the biological functions and disease categories presented ranged from 0 to 9 (please see Supplementary Table 3 for the number of SDEGs in individual categories).