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. 2020 Sep 25;178(2):375–390. doi: 10.1093/toxsci/kfaa146

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Published by Oxford University Press on behalf of the Society of Toxicology 2020.

This work is written by US Government employees and is in the public domain in the US.

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Figure 7. — Enrichment of cancer-related biological functions in the lungs of the tobacco smoke (TS)-, crystalline silica (CS)-, and TS plus CS-exposed rats. Gene expression profiles in the lungs of the rats were determined by next generation sequencing and significantly differentially expressed genes (SDEGs) in the TS, CS, and TS + CS exposure groups, compared with the control group, were identified as described in the text. The SDEGs identified in the TS-, CS-, and TS + CS-exposed rat lungs were used as input to identify the significantly enriched (p < .05) cancer-related biological functions using the Ingenuity Pathway Analysis (IPA) program as described in the text. The number of unique and overlapping cancer-related biological functions significantly enriched (p < .05) in the lungs of the rats is presented.