Table 4.
Fold Changes in the Expressions of Differentially Expressed Transcripts in the Lungs of the TS-, CS-, and TS + CS-Exposed Rats
| Fold Change in Expression |
|||
|---|---|---|---|
| Transcript | TS | CS | TS + CS |
| Adenosine A1 receptor (ADORA1) | 1.47 | 4.02 | 5.24 |
| C-C motif chemokine ligand 2 (CCL2) | 3.49 | 18.75 | 26.84 |
| Chitinase, acidic (CHIA) | 2.21 | 7.64 | 14.52 |
| Dual oxidase 1 (DUOX1) | 1.06 | 1.97 | 3.78 |
| Dual oxidase maturation factor 1 (DUOXA1) | 1.07 | 2.34 | 2.45 |
| Estrogen receptor 1 (ESR1) | 1.36 | 3.67 | 4.99 |
| Heme oxygenase 1 (HMOX1) | 1.37 | 2.74 | 3.17 |
| Lactoperoxidase (LPO) | 9.79 | 217.22 | 354.13 |
| Matrix metallopeptidase 7 (MMP7) | 1.28 | 6.01 | 7.90 |
| Matrix metallopeptidase 12 (MMP12) | 2.42 | 14.21 | 18.82 |
| Matrix metallopeptidase (MMP14) | 1.07 | 1.34 | 1.66 |
| Matrix metallopeptidase 19 (MMP19) | 1.07 | 1.21 | 1.57 |
| Neutrophil cytosolic factor 1 (NCF1) | 1.26 | 1.65 | 2.58 |
| Neutrophil cytosolic factor 2 (NCF2) | 1.18 | 1.84 | 2.03 |
| Neutrophil cytosolic factor 4 (NCF4) | 1.16 | 1.62 | 1.76 |
| NADPH oxidase organizer 1 (NOXO1) | 1.95 | 4.08 | 3.64 |
| PENTRAXIN3 (PTX3) | 2.01 | 3.46 | 5.41 |
| Phospholipase A2 group IB (PLA2G1B) | 1.24 | 1.83 | 2.09 |
| Phospholipase A2, group IVE (PLA2G4E) | 1.02 | 4,06 | 5.88 |
| Phospholipase A2 group VII (PLA2G7) | 1.19 | 1.88 | 2.50 |
| Resistin like alpha (RETNLA) | 1.23 | 15.80 | 31.34 |
| S100 calcium-binding protein A8 (S100A8) | 1.80 | 3.89 | 4.83 |
| S100 calcium-binding protein A9 (S100A9) | 2.31 | 8.87 | 9.92 |
| S100 calcium-binding protein A10 (S100A10) | 1.00 | 1.32 | 1.61 |
| Solute carrier family 26 member 4 (SLC26A4) | 4.09 | 24.15 | 30.58 |
| Superoxide dismutase 2 (SOD2) | 1.34 | 2.38 | 2.35 |
| Secreted phosphoprotein 1 (SPP1) | 2.85 | 36.69 | 72.61 |
The transcripts listed are those that are discussed in detail in the manuscript with respect to their potential role in CS-induced lung toxicity and exacerbation of the toxicity by TS. A complete list of all the transcritps detected in the rat lungs, fold changes in their expressions, and the adjusted p values are presented in Supplementary Table 2.