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. 2020 Aug 7;47(1):149–159. doi: 10.1093/schbul/sbaa105

Table 1.

Arcuate Fasciculus Findings in Sz

Reference Participants Field Strength Findings
Abdul-Rahman et al28 32 Sz
44 HC
3T Sz had lower FA in left frontal arcuate fasciculus
Sz had higher FA and AD in left temporal arcuate fasciculus
FA and AD correlated positively with severe positive symptoms
Boos et al29 126 Sz
123 nonpsychotic siblings
109 HC
1.5T FA in arcuate fasciculus negatively correlated with PANNS positive, negative, general, and total symptom scores
Siblings had higher FA than Sz and HC
Burns et al30 30 Sz
30 HC
1.5T Sz had lower FA in left arcuate fasciculus
Kubicki et al31 21 Sz
26 HC
1.5T Sz had lower FA in left arcuate fasciculus
Catani et al32 17 AH+
11 AH-
59 HC
1.5T Sz had lower FA in left and right arcuate fasciculus
AH+ had lower FA in left and right arcuate fasciculus
AH- had lower FA in left and right arcuate fasciculus
Ćurčić-Blake18 17 AH+
14 AH-
14 HC
3T AH+ had lower FA in anterior left and right arcuate fasciculus
de Weijer et al33 44 AH+
42 HC
3T AH+ had lower FA in left and right arcuate fasciculus
de Weijer et al34 35 Sz AH+
35 nonpsychotic AH+
36 HC
3T Sz AH+ had lower FA in left arcuate fasciculus than HC and nonpsychotic AH+
Hubl et al14 13 AH+
13 AH-
13 HC
1.5T FA higher in right vs left arcuate fasciculus
AH+ had higher FA in left lateral arcuate fasciculus than AH- or HC
AH+ and AH- had lower FA in medial left arcuate fasciculus
McCarthy-Jones et al35 18 Current AH+
21 Remitted AH+
40 non-auditory hallucinations
34 no hallucinations
40 HC
1.5T AH+ had lower FA in left arcuate fasciculus versus HC or AH-
AH+ had lower FA in left arcuate fasciculus than AH- w/ hallucinations in other modalities
FA of left arcuate fasciculus had nonlinear relationship with AH state
Phillips36 23 Sz
22 HC
1.5T Sz had lower FA in left arcuate fasciculus
Sz had lower volume of left arcuate fasciculus
Rotarska-Jagiela et al37 24 AH+ paranoid Sz
24 HC
3T Sz had higher FA in arcuate fasciculus than HC
FA in left arcuate fasciculus correlated positively with positive PANSS factor and AH severity
Seok et al38 15 AH+
15 AH-
22 HC
1.5T Both AH+ and AH- had lower FA in the anterior superior longitudinal fasciculus
Shergill et al39 9 Current AH+
17 Remitted AH+
7 AH-
40 HC
1.5T Sz had lower FA in right frontal and temporal-parietal portions of superior longitudinal fasciculus
FA of lateral aspect of left and right superior longitudinal fasciculus positively correlated with “propensity for auditory hallucinations”

Note: Sz, schizophrenia; FESz, first-episode schizophrenia; HC, healthy comparison subjects; AH+, hallucinations present; AH-, no hallucinations; T, Tesla; FA, fractional anisotropy; AD, axial diffusivity; PANSS, Positive and negative Syndrome Scale.