Table 2.

Arcuate Fasciculus Findings in Early Schizophrenia

Reference	Participants	Field Strength	Findings
Cheung et al41	25 FESz 26 HC	1.5T	No FA differences
Cheung et al43	34 FESz 32 HC Includes participants from Cheung et al43	1.5T	FESz had lower FA in left superior temporal gyrus (right frontal lobe, left anterior cingulate gyrus, etc.) FESz with more positive symptoms had FA values closer to controls
Douaud et al44	25 adolescent onset Sz 25 HC	1.5T	Sz had reduced FA in left arcuate fasciculus
Karlsgodt et al46	12 recent-onset Sz 17 HC	1.5T	Sz had lower FA in superior longitudinal fasciculus; particular deficit in left hemisphere
Mandl et al47	16 FESz 23 HC	1.5T	Group differences between FESz and HC in left arcuate fasciculus from combined FA, mean diffusivity, magnetization transfer ratio values
Peters et al42	10 FESz (first or second episode) 10 UHR 10 HC	3T	No FA differences
Szeszko et al45	10 FESz 13 HC	1.5T	FESz had lower FA in left posterior superior temporal gyrus (primary auditory cortex)
Whitford et al27	51 Early Course Sz 40 CHR 59 HC	3T	ESz had lower FA in arcuate fasciculus than CHR and HC ESz had higher radial diffusivity in arcuate fasciculus than CHR and HC

Note: Sz, schizophrenia; ESz, early course schizophrenia; FESz, first-episode schizophrenia; HC, healthy comparison subjects; AH+, hallucinations present; AH-, no hallucinations; UHR, ultra-high risk for psychosis; CHR, clinical high risk for psychosis.