Table 2.
PD-L1/PD-1 regulation in MM niche by immunomodulatory drugs (IMiDs).
| IMiD | MM Cells | T Cells | NK Cells | Monocytes/ MDSCs |
Ref |
|---|---|---|---|---|---|
| Lenalidomide | PD-L1 down-regulated |
PD-1 down-regulated | PD-1 down-regulated | PD-L1 down-regulated | [39] |
| PD-L1 up-regulated in IMiDs resistant cells |
[64] | ||||
| Pomalidomide | PD-L1 down-regulated |
- | - | PD-L1 down-regulated | [65] |
| PD-L1 up-regulated in IMiDs resistant cells |
[64] | ||||
| Thalidomide | - | - | - | - |
Abbreviations: MDSCs, myeloid derived suppressor cells; MM, multiple myeloma; NK, natural killer; Ref, references; -, data not available.