Table 4.
Univariate and multivariate COX regression analyses for patients with isolated distant lymph node metastases
| Features | Overall survival | Cancer specific survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age | ||||||||
| < 60 | 1.000 (Reference) | 1.000 (Reference) | ||||||
| 60–69 | 0.761 (0.393–1.472) | 0.416 | 0.755 (0.390–1.463) | 0.405 | ||||
| 70–79 | 1.054 (0.554–2.006) | 0.872 | 0.957 (0.497–1.845) | 0.897 | ||||
| ≥ 80 | 1.695 (0.691–4.160) | 0.249 | 1.726 (0.703–4.239) | 0.234 | ||||
| Gender | ||||||||
| Male | 1.000 (Reference) | 1.000 (Reference) | ||||||
| Female | 0.747 (0.453–1.232) | 0.254 | 0.710 (0.429–1.177) | 0.184 | ||||
| Marriage | ||||||||
| Married | 1.000 (Reference) | 1.000 (Reference) | ||||||
| Unmarried | 0.615 (0.363–1.042) | 0.071 | 0.645 (0.379–1.097) | 0.106 | ||||
| Unknown | 1.133 (0.348–3.691) | 0.836 | 1.208 (0.370–3.944) | 0.755 | ||||
| Race | ||||||||
| White | 1.000 (Reference) | 1.000 (Reference) | ||||||
| Black | 0.491 (0.225–1.071) | 0.074 | 0.510 (0.233–1.115) | 0.091 | ||||
| Others | 0.741 (0.377–1.457) | 0.385 | 0.770 (0.391–1.518) | 0.450 | ||||
| Grade | ||||||||
| I | 1.000 (Reference) | 1.000 (Reference) | ||||||
| II | 0.466 (0.102–2.132) | 0.325 | 0.466 (0.102–2.133) | 0.325 | ||||
| III + IV | 1.133 (0.257–4.985) | 0.869 | 1.061 (0.240–4.700) | 0.938 | ||||
| Unknown | 1.465 (0.350–6.129) | 0.601 | 1.436 (0.343–6.015) | 0.621 | ||||
| T stage | ||||||||
| T0 | 1.000 (Reference) | 1.000 (Reference) | ||||||
| T1 | 0.513 (0.114–2.309) | 0.385 | 0.510 (0.113–2.297) | 0.381 | ||||
| T2 | 0.340 (0.087–1.328) | 0.121 | 0.330 (0.084–1.295) | 0.112 | ||||
| T3 | 0.483 (0.145–1.612) | 0.237 | 0.441 (0.132–1.481) | 0.185 | ||||
| T4 | 0.788 (0.202–3.070) | 0.731 | 0.785 (0.201–3.062) | 0.728 | ||||
| TX | 0.946 (0.272–3.286) | 0.930 | 0.943 (0.271–3.278) | 0.926 | ||||
| N stage | ||||||||
| N0 | 1.000 (Reference) | 1.000 (Reference) | ||||||
| N1 | 0.623 (0.315–1.229) | 0.172 | 0.610 (0.303–1.229) | 0.167 | ||||
| N2 | 0.757 (0.417–1.375) | 0.360 | 0.794 (0.433–1.455) | 0.455 | ||||
| NX | 0.705 (0.278–1.787) | 0.461 | 0.738 (0.289–1.885) | 0.525 | ||||
| Surgery at primary site | ||||||||
| Yes | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
| No | 2.410 (1.389–4.181) | 0.002 | 3.575 (1.968–6.494) | < 0.001 | 2.326 (1.335–4.053) | 0.003 | 3.435 (1.883–6.268) | < 0.001 |
| Radiation | ||||||||
| Yes | 1.000 (Reference) | 1.000 (Reference) | ||||||
| No | 2.061 (0.799–5.321) | 0.135 | 2.020 (0.781–5.224) | 0.147 | ||||
| Chemotherapy | ||||||||
| Yes | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
| No | 2.426 (1.464–4.019) | 0.001 | 3.667 (2.108–6.377) | < 0.001 | 2.421 (1.449–4.045) | 0.001 | 3.622 (2.065–6.353) | < 0.001 |
| Tumor size | ||||||||
| < 3 cm | 1.000 (Reference) | 1.000 (Reference) | ||||||
| < 5 cm | 1.649 (0.588–4.621) | 0.342 | 1.675 (0.597–4.701) | 0.327 | ||||
| ≥ 5 cm | 1.234 (0.474–3.215) | 0.667 | 1.143 (0.434–3.011) | 0.786 | ||||
| Unknown | 2.494 (1.032–6.024) | 0.042 | 2.457 (1.014–5.954) | 0.046 | ||||
Other races include Asian or Pacific Islander and American Indian/Alaska Native; Grade I = well differentiated, II = moderately differentiated, III = poorly differentiated, IV = undifferentiated; HR = hazard ratio; CI = confidence interval