Figure 2.

Simulated vs. observed survival for Response Evaluation Criteria in Solid Tumors–based subgroups: (a) COX model, (b) JM SLD model, (c) and multivariate JM SLD&NLR model. JM simulations made use of 3 months of longitudinal SLD and NLR data. Ranges (in various colors) represent the 50% range for the simulated survival curves. Solid lines represent simulated median survival. Dashed lines represent observed Kaplan–Meier estimates for subgroups of patients. COX, Cox proportional hazards model; CR, complete response; JM, joint model; NLR, neutrophil‐to‐lymphocyte ratio; PD, progressive disease; PR, partial response; SD, stable disease; SLD, sum of the longest diameters.