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. 2021 Jan 22;9:22. doi: 10.1186/s40168-020-00963-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5. — Microbiome treatment affects cell proliferation. a Heat map showing the expression of genes in the ‘Regulation of cell proliferation’ gene set. b Normalized counts of the MIK67 transcript in each treatment condition. c The number of KI67⁺ cells counted in each treatment condition, across five tissues. * indicates condition is different from the axenic control, one-way ANOVA followed by Dunnett’s multiple comparisons test against the axenic control, p < 0.05. d Representative immunofluorescence images of each treatment conditions showing DAPI-stained nuclei in blue and KI67 in red. All scale bars indicate 100 μm