Table 2.

Study outcomes

Outcomes			Instruments
Primary outcome	HRQoL		SF-12 physical and mental component scores [28]
Secondary outcomes	Clinical outcomes	Mortality (all-cause)	ERA-EDTA codes [16, 47]
		Hospitalisation (all-cause)	ICD-10 codes [48]
		Functional status	Katz-ADL [14], Lawton-iADL [15]
		Cognitive functioning	MoCA [17], 6-CIT [18], LDST [20]
		Frailty	Clinical Frailty Scale [25]
	Cost-effectiveness		ICERs, calculated using EQ-5D-5 L [30] and iPCQ/iMCQ [32, 33]
	Decisional regret		Decisional Regret Scale [36]

All outcomes are repeated measures during the first year of the second stage (Fig. 1)

Abbreviations: 6-CIT six-item Cognitive Impairment Test, EQ-5D-5L Five-level EQ-5D, ERA-EDTA European Renal Association - European Dialysis & Transplant Organisation, HRQoL Health-Related Quality of Life, (i) ADL (Instrumental) Activities of Daily Living, ICD-10 International Statistical Classification of Diseases, 10th edition, ICER Incremental Cost-Effectiveness Ratio, iMCQ iMTA Medical Costs Questionnaire, iPCQ iMTA Productivity Cost Questionnaire, LDST Letter-Digit Substitution Test, MoCA Montreal Cognitive Assessment, QALY Quality Adjusted Life Year, SF-12 Twelve-item Short Form Health Survey