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. 2021 Jan 21;9(1):e001481. doi: 10.1136/jitc-2020-001481

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Tumor cell clearance activity of phagocytes was enhanced after ROCK signaling inhibition of BMDMs and BMDCs. (A–D) Phagocytic activity of (A, B) BMDMs and (C, D) BMDCs after ripasudil (30 μm) treatment or non-treatment for 1 hour and further cocultured with non-treated or FIC-PDT pretreated B16F10 cells for 30 min. Engulfed B16F10 cells by BMDMs and BMDCs were assessed by flow cytometry (A, C) and CLSM (B, D). One-way ANOVA followed by Tukey’s posthoc test was used for statistical analysis; *p<0.05, **p<0.01, ***p<0.001. Data are presented as the mean±SD. ANOVA, analysis of variance; BMDC, bone marrow-derived dendritic cell; BMDM, bone marrow-derived macrophage; CLSM, Confocal laser scanning microsope; FIC-PDT, PDT with Ce6-embedded nanophotosensitizer; PDT, photodynamic therapy; ROCK, rho-kinase.