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. 2021 Jan 21;9(1):e001481. doi: 10.1136/jitc-2020-001481

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Abscopal effect of local administration of FIC-PDT and ripasudil combined with α-PD-L1 antibody. (A) Treatment schedule for abscopal animal model after various treatments. (B) Tumor growth curves of primary and secondary tumors (n=8–12 per group). (C, D) Percentage of CD103-expressing DCs (C) and CD44⁺CD8⁺ T cells (D) in TDLNs. (E, F) Percentage of CD8⁺ T cells (E) and granzyme B⁺ T cells (F) in primary and secondary tumors was quantified by flow cytometry. (G) Ratio of CD8⁺ T cells over regulatory (CD25⁺CD4⁺) T cells in primary and secondary tumors. One-way ANOVA followed by Tukey’s posthoc test was used for statistical analysis; *p<0.05, **p<0.01, ***p<0.001. Data are presented as the mean±SEM. ANOVA, analysis of variance; FIC-PDT, PDT with Ce6-embedded nanophotosensitizer; PDT, photodynamic therapy; TDLN, tumor draining lymph node.