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. 2021 Jan 21;9(1):e001481. doi: 10.1136/jitc-2020-001481

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Antitumor effect, immune context conversion, and metastasis inhibition after each treatment in orthotopic intraocular melanoma model. (A) Treatment schedule for orthotopic intraocular melanoma model. (B) Tumor weights excised from orthotopic mouse model on day 20 after tumor inoculation. (C, D) Observable metastatic nodules in the lung. Representative images of lungs in each group (C) and number of metastatic nodules in the lung after various treatments (D). One-way ANOVA followed by Tukey’s posthoc test was used for statistical analysis; *p<0.05, **p<0.01, ***p<0.001. Data are presented as the mean±SEM. ANOVA, analysis of variance; FIC-PDT, PDT with Ce6-embedded nanophotosensitizer; PDT, photodynamic therapy.