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. 2021 Jan 21;9(1):e001481. doi: 10.1136/jitc-2020-001481

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Population and location of immune cell subsets in tumor using multiplex IHC. (A) Exact location and density of CD8⁺ cells (green) and PD-L1⁺ cells (red) in the TME were investigated using multiplex IHC. (B) Tumor tissues were stained with Ki67 (green), PD-L1 (red), FOXP3 (orange), CD8 (white) and nuclei was costained with DAPI (blue). Yellow arrows represents the proliferative CD8⁺ T cells. (C) Percentage of proliferative CD8+ (Ki67⁺CD8⁺) cells. IHC, immunohistochemistry; TME, tumor microenvironment.