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. 2021 Jan 21;9(1):e001807. doi: 10.1136/jitc-2020-001807

Figure 3.

Figure 3

CD8+CD103+ TRMs are more frequent in cSCC than in blood and normal skin (NS). (A) Representative FACS plots from blood, NS and cSCC from the same patient showing expression of CD69 (X-axis) and CD103 (Y-axis) in CD3+, CD4+FOXP3+, CD4+ FOXP3− and CD8+ gated populations. (B–F) Graphs showing frequencies of cells based on CD69 and CD103 expression as percentages of (B) CD3+, (C) CD4+ FOXP3+, (D) CD4+ FOXP3−, (E) total CD4+ and (F) CD8+ populations. (G) Graph showing percentages of CD103+ T cells that are CD4+ FOXP3+, CD4+ FOXP3−, CD4+ and CD8+. (H) Percentages of the live lymphocyte population expressing CD103 in blood, NS and cSCC. (I) Percentages of the CD3+ (left), CD4+ (center) and CD8+ (right) T-cell populations from blood, normal skin and cSCC that are CD69+CD103+ TRMs. n=36 tumors for all graphs except (C) and (D), where n=9 tumors. Horizontal bars=means, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. cSCC, cutaneous squamous cell carcinoma; TRMs, resident memory T cells.