Table 2.

Dose Levels and Dose-limiting Toxicities (DLTs).

Dose Level	Veliparib Dose (mg BID)	Carboplatin Dose (AUC)	Paclitaxel Dose (mg/m2)	# Enrolled	# Evaluable for DLT	DLTs
Level 1	10	6	150	5	3	0
Level 2	20	6	150	8	7	Grade 3 neutropenia > 7 days
Level 3	20	6	175	3	3	0
Level 4	40	6	175	3	3	0
Level 5	40	6	200	13	6	Grade 3 febrile neutropenia
Level 6	50	6	200	5	3	0
Level 7	80	6	200	11	6	Grade 3 febrile neutropenia
Level 7B	100	6	200	15	14	Grade 4 sepsis and neutropenia Grade 4 neutropenia Grade 4 febrile neutropenia and Grade 3 fatigue
Level 8	120	6	200	10	7	Grade 4 hyponatremia, Grade 3 nausea Grade 3 febrile neutropenia