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The role of the receptors in the activation of signaling pathways in GISTs. The four major receptors groups (RTKs, PDGFR, c-KIT, and VEGFR) closely regulate the cellular process such as angiogenesis, cell proliferation and motility, and anti-apoptotic capability of cancer cells through the induction of RAF/MEK/ERK, PI3K/AKT/mTOR, PKC, and Src/FAK axis. In addition, a plethora of small agents that directly target the receptors or signaling pathways is presented in the figure.
