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. 2021 Jan 20;9:e10749. doi: 10.7717/peerj.10749

Table 2. The biological functions of the coding genes.

Gene Immune-related functions
CD70 CD70 belongs to TNF ligand family and can enhance the generation of cytolytic T cells and induce proliferation of co-stimulated T cells (Keller et al., 2007; Kuka et al., 2013). The regulatory mechanisms for the CD70-CD27 pathway is critical for prognosis of cancer patients.
CXorf21 CXorf21 is a mediator of the X-chromosome gene of systemic lupus erythematosus in female (Bentham et al., 2015; Harris et al., 2019b) and is expressed only in immune cell (Harris et al., 2019a).
CD74 CD74 expression serves as a prognostic factor in many cancers (Ekmekcioglu et al., 2016; Otterstrom et al., 2014; Ruvolo et al., 2019; Zeiner et al., 2015; Zeiner et al., 2018; Zhang et al., 2014).
RUBCNL RUBCNL is a vertebrate-specific autophagy regulator (Cheng et al., 2017), and involves autophagy in NSCLC (Levy, Towers & Thorburn, 2017).
BIRC3 BIRC3 involves in the prognostication system in Chronic Lymphocytic Leukemia (Alhourani et al., 2016) and hepatocellular carcinoma patients undergoing curative resection (Fu et al., 2019).
TESC TESC can reinforce the radio-resistant properties of NSCLC (Lee et al., 2018).
INSL4 Abnormal INSL4 signaling may act as a promising therapeutic target for LKB1-deficient NSCLC (Yang et al., 2018).
HLA-DOB HLA-DOB are expressed in antigen presenting cells which is tightly linked with the immunity.
CIITA The vaccination with CIITA-tumour cells is constructed to facilitate anti-tumour cells to enhance the immune system (Accolla et al., 2019).
STAP1 No relevant report yet.
OBP2A No relevant report yet.