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. 2021 Jan 6;11(1):31. doi: 10.3390/jpm11010031

Figure 1.

Figure 1

Candidate microRNAs (miRNAs) and their target proteins. (a) High levels of miR-210 in women with breast cancer (BC) leads to increased levels of hypoxia-inducible factor 1-alpha (HIF-1α) (activates a looping cascade) and, in addition, there is no blocking of HIF-1α by Von Hippel–Lindau (VHL) protein. Elevated levels of HIF-1α lead to an increase in vascular endothelial growth factor (VEGF). (b) With regard to miR-152, there is a low expression of this miRNA in women with BC, which leads to the increase of the IGF-1R protein and, later, of the VEGF protein.